Reduction of Murine Cutaneous UVB-Induced Tumor-Infiltrating T Lymphocytes by Dietary Canthaxanthin
نویسندگان
چکیده
منابع مشابه
T-cell activation marker expression on tumor-infiltrating lymphocytes as prognostic factor in cutaneous malignant melanoma.
The central role of T cells in antitumor immunity is well established. However, tumor progression, often seen in the presence of substantial lymphocytic infiltration, suggests that these T cells are not capable of mounting an effective immune response to control tumor growth. Evidence has accumulated that T lymphocytes infiltrating human neoplasms are functionally defective, incompletely activa...
متن کاملModulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.
Stimulating the effector functions of tumor-infiltrating T lymphocytes (TIL) in primary and metastatic tumors could improve active and adoptive T-cell therapies for cancer. Abnormal glycolysis, high lactic acid production, proton accumulation, and a reversed intra-extracellular pH gradient are thought to help render tumor microenvironments hostile to roving immune cells. However, there is littl...
متن کاملTumor Infiltrating Lymphocytes
9 Abstract 10 11 Tumor infiltrating lymphocytes (TILs) have been recognized in various 12 cancers and may reflect a host immune response to malignant cells. TILs 13 are a heterogeneous population of various types of mononuclear cells, 14 including CD8 or CD4 + T cells and their subsets, B cells, myeloid 15 derived suppressor cells (MDSC), macrophages, and other cells. Immuno16 suppressive facto...
متن کاملT cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3
Regulatory T cells (Treg) that express the transcription factor Foxp3 are enriched within a broad range of murine and human solid tumors. The ontogeny of these Foxp3 Tregs - selective accumulation or proliferation of natural thymus-derived Treg (nTreg) or induced Treg (iTreg) converted in the periphery from naïve T cells - is not known. We used several strains of mice in which Foxp3 and EGFP ar...
متن کاملInterferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes
We have investigated the mechanisms whereby adoptively transferred murine CD8+ lymphocytes mediate tumor regressions. Noncytolytic, CD8+ tumor-infiltrating lymphocytes (TIL) eradicated established lung tumors in irradiated mice. Many cytolytic and noncytolytic CD8+ TIL cultures specifically secreted interferon gamma (IFN-gamma) and tumor necrosis factor when stimulated with tumor cells in vitro...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1991
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12491637